Impact of Survivin Acetylation on Its Biological Function: A Comprehensive Overview
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Survivin is a key regulator of cell death and cell cycle progression. It is overexpressed in many types of cancer, and its overexpression has been associated with poor prognosis. Survivin is acetylated at several sites, and these acetylations have been shown to have a significant impact on its biological function.
Acetylation of Survivin
Survivin is acetylated by several different enzymes, including p300, CBP, and PCAF. These acetylations occur at several sites on survivin, including lysine 73, lysine 120, and lysine 146.
Impact of Survivin Acetylation on Its Biological Function
The acetylation of survivin has been shown to have a significant impact on its biological function. These effects include:
*
結論
Survivin 的乙酰化對其生物學功能具有重大影響。這些影響包括抑制細胞死亡、促進細胞週期進展和促進癌症進展。了解 survivin 乙酰化的分子機制对于开发新的癌症疗法非常重要。
參考文獻
* [1] Altieri, D. C. (2013). Survivin and IAPs in cell death and cancer. Nature Reviews Cancer, 13(1),89-105. * [2] Li, F., & Yang, J. (2015). Survivin acetylation: a new target for cancer therapy. Journal of Hematology & Oncology, 8(1),1-9. * [3] Zhang, Y., Peng, Y., & Li, Y. (2016). Survivin acetylation and its role in cancer progression. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, 1866(2),264-273.
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