Mitochondrial Dynamics in Cardiovascular Medicine: Advances in Experimental and Therapeutic Approaches

Mitochondrial Dynamics in Cardiovascular Medicine (Advances in Experimental Medicine and Biology Book 982)

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Mitochondria are essential organelles that play a critical role in cellular metabolism, energy production, and apoptosis. Mitochondrial dynamics, which refers to the continuous fusion and fission of mitochondria, is a highly regulated process that is important for maintaining mitochondrial function and cellular homeostasis.

In the cardiovascular system, mitochondrial dynamics is essential for the proper function of the heart and blood vessels. Alterations in mitochondrial dynamics have been implicated in the development of cardiovascular diseases such as heart failure, ischemia-reperfusion injury, and atherosclerosis.

This book provides a comprehensive overview of the latest advances in our understanding of mitochondrial dynamics in cardiovascular medicine. It covers both experimental and therapeutic approaches to targeting mitochondrial dynamics for the treatment of cardiovascular diseases.

Experimental Approaches

The book begins with a discussion of the experimental approaches that have been used to study mitochondrial dynamics in cardiovascular cells. These approaches include:

• Microscopy techniques, such as live-cell imaging and electron microscopy, to visualize mitochondrial dynamics
• Biochemical assays to measure mitochondrial fusion and fission proteins
• Genetic approaches, such as gene knockout and overexpression, to study the role of specific mitochondrial dynamics proteins
• Animal models of cardiovascular disease, such as heart failure and ischemia-reperfusion injury, to investigate the role of mitochondrial dynamics in disease pathogenesis

Therapeutic Approaches

The book then discusses the therapeutic approaches that are being developed to target mitochondrial dynamics for the treatment of cardiovascular diseases. These approaches include:

• Pharmacological inhibitors of mitochondrial fusion and fission proteins
• Gene therapy to overexpress or knock down mitochondrial dynamics proteins
• Stem cell therapy to deliver mitochondria to damaged cardiac cells
• Exercise training, which has been shown to improve mitochondrial dynamics and function

Mitochondrial dynamics is a critical process for the proper function of the cardiovascular system. Alterations in mitochondrial dynamics have been implicated in the development of cardiovascular diseases. This book provides a comprehensive overview of the latest advances in our understanding of mitochondrial dynamics in cardiovascular medicine. It covers both experimental and therapeutic approaches to targeting mitochondrial dynamics for the treatment of cardiovascular diseases.

Mitochondrial Dynamics in Cardiovascular Medicine (Advances in Experimental Medicine and Biology Book 982)

5 out of 5

FREE